Police are investigating the cause of crash which has left a woman in a critical condition in hospital.
Just before 10am on Saturday, police and emergency services were called to the single vehicle crash on Glenlusk Road at Collinsvale.
Police say a Subaru station wagon had left the road, slid down an embankment and collided with some trees. The driver, a woman in her 20's, was transported to the Royal Hobart Hospital with critical injuries.
Glenlusk Road was closed for 2 and a half hours while the scene was investigated and cleared.
Anyone who may have witnessed the crash is asked to call the Glenorchy Police Station on 131 444 or you can provide information to Crime Stoppers on 1800 333 000 or at crimestopperstas.com.au.